When it came to decorating their home on Manhattan’s Upper East Side, Amy Schultz and her husband, noted dermatologist and BeautyRx founder Dr. Neal Schultz, found inspiration in a familiar setting: picturesque views of the East River.

“Overlooking the East River provides a sense of peace that is very rare for a New York City apartment, and we chose to decorate it using colors similar and related to the water,” Amy Schultz said.

It doesn’t hurt that the Yorkville apartment, now for sale at $3.995 million, is in a prime position for enjoying the sights. Located at 52 East End Avenue, the 35th-floor apartment features wall-to-wall windows that frame spectacular river and skyline views. Two private balconies also take in season-changing sights extending as far as the eyes can see.

“The sunlight floods the apartment from sunrise to sunset, and then, at dusk, the city “light show veins,” continuing an incredible visual experience,” said Dr. Neal Schultz, who has been featured in such publications as Shape, Elle, GQ and Allure and hosts the YouTube channel DermTV. “And yet, it’s a different experience every single day and night.”

The more than 2,600-square-foot apartment has a sunny and cheerful disposition driven by an expressive use of color and texture, according to Dr. Schultz. The centerfold-worthy residence is embellished in gold accents and has light hardwood floors and white walls that keep the atmosphere warm and bright. 

In the living room, expanses of glass converge at a centerpiece fireplace decorated in glittering tile. A gleaming chef’s kitchen sits off the space and has gold hardware and a matching backsplash that pops against the custom white-hued cabinetry. A formal dining room with its own skyline is adjacent to the kitchen.

The apartment has four en-suite bedrooms including an enhanced primary bedroom with a dressing area and a spa-like bathroom. Custom California Closets are prevalent throughout the home, as are Nest thermostats and window shades. Phillip Jeffries wallcoverings provide another textured element.

Located a block from the East River and near Carl Schurz Park, the full-service boutique building provides residents with 24-hour door staff, a concierge and a fitness center. But the real prize may be its proximity to the Upper East Side and Midtown.

“It’s location is great—I never have to gamble on whether or note to take the FDR, or whether there are parking available at Costco,” Dr. Schultz said.

The apartment is listed for sale by Annie Cion Gruenberger and Rebecca Blacker of Warburg Realty, an exclusive member of Forbes Global Properties.